Why is folate important? Folate is an essential nutrient best known for supporting neural tube development during pregnancy. But for everyone else, folate is still a must-have. It’s involved in multiple processes, including DNA methtylation.

Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.* A ......

What Studies Have Shown about 5-MTHF? Many studies have been conducted over the years comparing supplementation of 5-MTHF with that of folic acid and the two main advantages (of 5-MTHF) that have been found are...

What Does L-5-methylfolate Do? L-5-methylfolate (together with vitamin B12) functions as a methyl group donor in a range of metabolic and nervous system processes, making it vital to numerous metabolic pathways in the body. L-5-methylfolate plays an essential role in methylation, it enables the con......

MTHFR (methylenetetrahydrofolate reductase) is a key enzyme in the process of folate metabolism, which can catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), as an indirect donor of methyl groups, then participate in the synthesis of purines and pyrimidin......

The answer is “YES”. Around 30% people have the MTHFR gene defect globally, folic acid can’t be absorbed by these people. So, it is necessary to them to use methylfolate which don’t need metabolism and can be adsorbed directly.